Researchers elucidate aging mechanisms and identify a biomarker for aging and overall health status

From Medical xpress

Aging is a systemic process that affects the entire body. Visible external signs of aging usually correspond to evidence of equivalent aging in the functioning of the internal organs. This indicates that skin cells age in tandem with other cells throughout the body, suggesting a mechanism whereby aging in one part of the body spreads systemically.

The Tsukuba research group began focusing on CtBP2 while working to elucidate the mechanisms responsible for obesity. This sensor molecule is known to respond to metabolism, and its activity has previously been reported to decrease in individuals with obesity, leading to metabolic syndrome. Furthermore, the activation of CtBP2 has demonstrated therapeutic effects.