RSS SubscribeNew vitamin B12 therapy shows promise against deadly brain cancer
From ScienceDaily
A newly published study in Oncoscience explores a potential new approach to treating glioblastoma, an aggressive form of brain cancer that remains extremely difficult to treat. The paper is titled “Selective blood-brain barrier penetration and tumor targeting of nitrosylcobalamin in glioblastoma: Pharmacokinetics, tissue distribution, and synergistic activity with trail and temozolomide.”
The research was led by first and corresponding author Joseph A. Bauer of Nitric Oxide Services, LLC and the Cleveland Clinic Foundation Taussig Cancer Center. The team investigated nitrosylcobalamin (NO-Cbl), a modified form of vitamin B12 that releases nitric oxide, to determine whether it could cross the blood-brain barrier (BBB) and selectively accumulate in glioblastoma tumors.
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