Scientists just cracked the mystery of why cancer immunotherapy fails

From ScienceDaily

A hidden stress pathway, TexPSR, has been identified as the key driver of T-cell exhaustion in cancer. Blocking it revives immune cells, boosting the power of immunotherapy. Credit: Shutterstock

In what experts are calling a paradigm-shifting landmark study, scientists from The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) report key findings about the underlying mechanisms of immune system stress response to protein misfolding, launching a new approach to cancer immunotherapy treatment targeting the protein production cycle.