Little-known psychedelic found to have a fascinating effect on cognitive flexibility after just a single dose

By Eric W. Dolan – PsyPost

A new study published in Molecular Psychiatry has revealed that a single dose of the psychedelic drug 2,5-dimethoxy-4-iodoamphetamine (DOI) can lead to long-lasting changes in brain structure and cognitive flexibility in mice. The researchers found that mice treated with DOI became more attuned to previously overlooked cues, allowing them to learn more efficiently from their experiences. These effects appeared to depend on the timing of drug administration and the animals’ experiences after the treatment.